A hemodialyzer, also known as an artificial kidney, is a critical medical device used in hemodialysis to filter and remove waste products, excess fluids, and toxins from the blood when the kidneys are no longer able to function properly.
It acts as the core component of the hemodialysis system, enabling blood purification by passing the patient’s blood through semi-permeable membranes that allow selective exchange of substances between the blood and dialysis fluid.
| Model | Hemodialyser | |||
| Size: | 1.4-2.0m2 | |||
| Specifi cation and Model | H-40 | H-60 | H-80 | H-200 |
| Effective Surface(m2) | 1.4 | 1.6 | 1.8 | 2 |
| Membrane Quantity | 8832 | 9984 | 11136 | 12288 |
| ID(m2) | 200±15 | 200±15 | 200±15 | 200±15 |
| Wall Thickness(μm) | 40±5 | 40±5 | 40±5 | 40±5 |
| Effective Length(mm) | 240±2 | 240±2 | 240±2 | 240±2 |
| Priming Volume(mL) | 78 | 86 | 99 | 108 |
| Maximum TMP(mm Hg) | 500 | 500 | 500 | 500 |
| Pressure Drop(mmHg) Qb=300ml/min | < 105 | < 105 | < 105 | < 105 |
Size: 1.4-2.0m2
Common Specifications of Hemodialyzers
Membrane Material
Polysulfone (PS)
Polyethersulfone (PES)
Polyamide (PA)
Cellulose acetate (less common)
Membrane Surface Area
Typically ranges from 1.0 m² to 2.5 m²
Common models: 1.2 m², 1.4 m², 1.6 m², 1.8 m², 2.0 m², 2.2 m²
Ultrafiltration Coefficient (Kuf)
Measures water permeability
Ranges from 10 to 80 mL/h/mmHg
Clearance Rates (at standard blood flow and dialysate flow rates)
Urea Clearance (Kᵤ): e.g. 180–250 mL/min
Creatinine Clearance: slightly lower than urea
β2-Microglobulin Clearance: indicates middle molecule removal (used to define high-flux dialyzers)
Fiber Inner Diameter
Typically 200–220 µm
Sterilization Method
ETO (Ethylene Oxide) sterilized
Steam sterilized
Gamma radiation sterilized
Flux Type
Low-flux dialyzer: smaller pore size, mainly for small molecule removal
High-flux dialyzer: larger pore size, can remove both small and middle molecular weight toxins
Usage
Single-use only (most modern dialyzers are designed for single patient use)
End Cap Color Coding (varies by manufacturer)
To distinguish membrane size or model type for safety and convenience

For single-use disposable dialyzers
✅ Step 1: Preparation
Prepare the dialysis machine and verify all components.
Check dialyzer model, membrane surface area, and sterilization method.
Ensure the packaging is intact and within the expiry date.
Remove the dialyzer from its sterile packaging.
Connect the arterial and venous blood lines to the dialyzer ports securely.
✅ Step 2: Priming the Dialyzer
Prime the dialyzer with isotonic saline to remove air and residual chemicals.
Use 0.9% sodium chloride (NaCl) solution.
Prime with 200–300 mL of saline (or as specified by manufacturer).
Ensure complete air removal from blood lines and dialyzer fibers.
Discard the priming solution to avoid contamination.
✅ Step 3: Vascular Access and Blood Flow
Establish patient vascular access and start blood flow.
Insert arterial and venous needles into the patient’s fistula or catheter.
Connect tubing to the patient and ensure secure fittings.
Start the blood pump, typically at 200–400 mL/min.
Monitor for any signs of air bubbles, leakage, or kinks in the tubing.
✅ Step 4: Dialysis Procedure
Conduct the dialysis session according to the prescribed treatment plan.
Dialysate flow: 500–800 mL/min.
Typical treatment duration: 3 to 5 hours.
Monitor transmembrane pressure (TMP), venous/arterial pressure, and ultrafiltration rate.
Observe patient vitals throughout the session.
✅ Step 5: Blood Return and Disconnection
Conclude the session and safely return blood to the patient.
Rinse the dialyzer and blood lines with saline to return residual blood.
Clamp tubing lines before disconnecting.
Remove needles carefully and apply pressure to access sites.
✅ Step 6: Disposal
Dispose of the used dialyzer and tubing per medical waste guidelines.
Treat as biohazardous waste.
Place used dialyzer in a sharps container or designated medical waste bag.
Document the procedure as per facility protocol.
Features
1. High hydraulic permeability
2. Lower resitance membrane
3. Higher permeability for middle to large size molecules
4. Excellent blood compatibility
Key Features of Hemodialyzers
High Biocompatibility
Made from advanced membrane materials (e.g., polysulfone, PES) that minimize immune reactions and improve patient comfort.
Efficient Toxin Removal
Effectively clears small and middle molecular toxins such as urea, creatinine, and β2-microglobulin to support blood purification.
Wide Range of Membrane Surface Areas
Available in multiple sizes (from 1.0 to 2.5 m²) to accommodate different patient needs and dialysis prescriptions.
High-Flux and Low-Flux Options
Offers flexibility in treatment based on clinical requirements — high-flux dialyzers enhance middle molecule clearance and ultrafiltration.
Strong Ultrafiltration Performance
Precise control over fluid removal with reliable ultrafiltration coefficients (Kuf), ensuring patient safety during dialysis.
Transparent Housing with Graduated Scale
Easy visual monitoring of blood flow and fluid level during treatment.
Safe and Sterile Packaging
Individually packed and sterilized by ETO, steam, or gamma radiation to ensure safety and hygiene.
Single-Use Design
Designed for single patient use to eliminate cross-contamination and ensure consistent performance.
Standardized Blood and Dialysate Ports
Compatible with most dialysis machines and tubing systems for easy integration.
Color-Coded End Caps (Optional)
For quick model identification and safe operation.
Chronic Kidney Disease (CKD) – Stage 5 / End-Stage Renal Disease (ESRD)
Used for regular hemodialysis treatment in patients whose kidneys have lost over 85–90% of their function.
Acute Kidney Injury (AKI)
Applied in critical care settings for temporary renal support in ICU patients with sudden loss of kidney function.
Hemodialysis Centers & Clinics
Core component of outpatient dialysis services; used for routine dialysis sessions (3 times per week, on average).
Hospitals / Nephrology Departments
Used for inpatient dialysis therapy, especially for patients recovering from surgery, trauma, or sepsis with renal complications.
Emergency and Disaster Relief
Deployed in mobile dialysis units or temporary facilities for patients affected by natural disasters or conflicts requiring renal support.
Home Hemodialysis Programs (selected models)
Compatible with certain compact dialysis machines used in home-care settings for trained patients under medical supervision.
Perioperative Renal Protection
In some high-risk surgeries (e.g., cardiac), dialysis may be required to support kidney function intra- or post-operatively.
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