Ehrlichia canis (EHR) is an obligate intracellular parasite that is mainly transmitted by brown dog ticks (Rhipicephalus sanguineus), infects canine monocytes and granulocytes, and causes canine monocytic erlichiosis (CME). The disease is distributed globally and is particularly prevalent in tropical and subtropical regions. After infection, specific antibodies (EHR Ab) are produced in dogs, and their levels reflect the stage of infection: IgM antibodies increase in the acute phase (1-3 weeks), and IgG antibodies are dominant in the chronic phase (more than several months).
Detection of EHR antibodies is crucial for clinical diagnosis, especially for dogs with unexplained fever, anemia, thrombocytopenia, and multiple organ dysfunction. The lateral flow immunochromatography kit can quickly and qualitatively detect EHR antibodies in serum, plasma, or whole blood by pre-coating recombinant antigens. If antibodies are present in the sample, they will bind to the test line (T line) and develop color, and the results can be read within 15-20 minutes. The technology is easy to use and suitable for on-site screening, but it needs to be combined with PCR or blood smear microscopy for further diagnosis.
Early diagnosis and treatment (such as doxycycline) can significantly improve prognosis, while chronic infection may lead to immunosuppression and even death. Regular screening and tick control are the key to prevention.
